TABLE 1.Effect of GCP II inhibition on intrinsic membrane properties
|
|||
Properties |
Control |
2-MPPA |
P |
Vm, mV | -64.2 ± 1.9 | -64.7 ± 1.7 | 0.59 |
Rm, MΩ | 223.8 ± 7.1 | 230.5 ± 8.7 | 0.64 |
τm, ms | 45.8 ± 7.1 | 49.9 ± 8.7 | 0.25 |
AP threshold, mV | -42.4 ± 3.1 | -41.2 ± 3.0 | 0.24 |
Rheobase, pA | 98.9 ± 1.8 | 98.1 ± 2.0 | 0.15 |
AP amplitude, mV | 105.7 ± 5.3 | 106.9 ± 5.6 | 0.65 |
ADP, mV | 3.3 ± 0.9 | 3.4 ± 1.0 | 0.82 |
fAHP, mV |
4.5 ± 0.5 |
4.9 ± 0.6 |
0.52 |
Recordings from CA3 pyramidal cells (n = 7) before (control) and after application of the glutamate carboxypeptidase II (GCP II) inhibitor, 2-(3-mercaptopropyl)-pentanedioic
acid (2-MPPA). Values are expressed as means ± SE. Vm, resting membrane potential; Rm, input resistance; τm, membrane time constant; AP, action potential; ADP, afterdepolarization; fAHP, fast afterhyperpolarizing potential. Statistical
comparisons performed by unpaired Student's t-test, P as indicated.